Epidemiology Project

Project: Environmental and Genetic Determinants of Puberty. This is a collaborative multi-site epidemiologic study of young girls.

The aim of these collaborative studies is to investigate and identify predictors of early age at onset of puberty, including breast and pubic hair development. The rationale underlying these studies is that early sexual maturation is associated with increased risk of breast cancer, and this may represent a critical period in establishing long-term breast cancer risk. Areas of interest include environmental exposures, including chemicals in personal and household products that may be hormonally active; lifestyle factors, such as food intake and physical activity; body size and development; and psychosocial factors.

These are prospective studies, enrolling young girls at age 6 to 8 years at first visit, and following them forward with periodic visits to assess hallmarks of pubertal development and changes in exposures of interest.

View baseline cohort make-up.

Center	P2 Principal Investigator	Study Population	Study Logo
FCCC	Mary Wolff, PhD Mt Sinai School of Medicine [email protected]	7- & 8-yr old girls from East Harlem Cohort includes Latina and African-American girls
UCSF/ Bay Area	Lawrence Kushi, ScD Kaiser Permanente, Div of Research [email protected]	7-yr old girls, members of Kaiser Permanente, in San Francisco, Marin, and Alameda Counties Cohort includes Asian, African-American, Latina and white girls
UC	Frank Biro, MD Cincinnati Children’s Hospital Medical Center [email protected]	6- & 7-yr old girls from greater Cincinnati metropolitan area (selected school districts in SW Ohio and Northern Kentucky) Cohort includes African-American, Asian, and white girls

 

Mary Wolff

Mt. Sinai School of Medicine, NY

Principal Investigator:	Mary Wolff, PhD
Co-investigator(s):	Susan Teitelbaum, PhD Maida Galvez, MD
Study Population:	7- & 8-yr old girls from East Harlem

 

Larry Kushi

Kaiser Permanente, Div of Research

Principal Investigator:	Lawrence Kushi, ScD
Co-investigator(s):	Christine Ambrosone, PhD, Roswell Park Cancer Institute Julie Deardorff, PhD, UC Berkeley Christine Erdmann, PhD, MPH, University of Michigan Robert Hiatt, MD, PhD, UC San Francisco Barbara Sternfeld, PhD, Kaiser Permanente, Div. of Research Gayle Windham, PhD, California Dept. of Public Health
Study Population:	7-yr old girls, members of Kaiser Permanente, in San Francisco, Marin, and Alameda Counties
website:	bayarea.bcerc.org/cygnet.htm

 

Frank Biro

Cincinnati Children’s Hospital Medical Center

Principal Investigator:	Frank Biro, MD [email protected]
Co-investigator(s):	Kim Dietrich, PhD Susan Pinney, PhD
Study Population:	6- & 7-yr old girls from greater Cincinnati metropolitan area (selected school districts in SW Ohio and Northern Kentucky)
website:	eh.uc.edu/growingupfemale/epidemiology_studies.asp