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Laboratory Research
Project: Environmental Effects on the Molecular Architecture and Function of the Mammary Gland across the Lifespan.
Coral Lamartiniere |
Fox Chase Cancer Center
| Principal Investigator: |
Coral Lamartiniere, PhD
University of Alabama at Birmingham |
| Co-investigator(s): |
Irma Russo, PhD
Fox Chase Cancer Center
Jose Russo, MD
Fox Chase Cancer Center
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| Animal Model: |
rat |
| Hypothesis: |
Exposure to estrogenically-active (endocrine-disrupting) chemicals during early development will alter predisposition to breast cancer later in life. |
| Website: |
http://labs.fccc.edu/bcrl/projects/project1.html |
Michigan State University
| Principal Investigator: |
Sandra Z. Haslam, PhD |
| Co-investigator(s): |
Richard Miksicek, PhD
Richard Schwartz, PhD
Tim Zacharewski, PhD |
| Animal Model: |
rat, mouse |
| Hypothesis: |
increased lifetime exposure to the proliferative effects (increase in number of cells) of progesterone is associated with the increased risk of breast cancer development. |
| Website: |
www.bcerc.msu.edu/science.html |
San Francisco Bay Area
| Principal Investigator: |
Zena Werb, PhD
University of California, San Francisco |
| Co-investigator(s): |
Mary-Helen Barcellos-Hoff, PhD
New York University Medical Center
Paul Yaswen, PhD
Lawrence Berkeley National Laboratory
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| Animal Model: |
mouse |
| Hypothesis: |
Environmental agents that increase breast cancer risk alter both mammary epithelial and stromal cell phenotypes; disruption of these crucial interactions affects the regulation of growth and differentiation of stem cells, which are a critical target of carcinogenesis.
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| Website: |
bayarea.bcerc.org/biology.html |
University of Cincinnati
| Principal Investigator: |
Marshall Anderson, PhD |
| Co-investigator(s): |
Debbie Clegg, PhD
University of Texas |
| Animal Model: |
rat |
| Hypothesis: |
Fatty acids, nutrition and obesity modify estrogen synthesis, metabolism and signaling, and define mammary gland rates of maturation and physiology of the animal in ways that impact mammary gland susceptibility to initiation.
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| Website: |
eh.uc.edu/growingupfemale/biology_studies.asp |
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