Environmental Effects on the Molecular Architecture and Function of the Mammary Gland across the Lifespan

In this project we are conducting studies on normal mammary glands at the molecular, cellular and organ level in mice that parallel the steps in the development of cancer. Models for breast cancer development will be used to understand how environmental factors regulate cell behavior during development and conversion to cancer.

Project Leader Zena Werb, PhD University of California San Francisco Co-Investigators Mary Helen Barcellos-Hoff, PhD Department of Radiation Oncology New York University Langone School of Medicine Paul Yaswen, PhD Lawrence Berkeley National Laboratory